The 1949 Little League World Series was held from August 24 to August 27 in Williamsport, Pennsylvania. The Hammonton All Stars of Hammonton, New Jersey, defeated the Pensacola All Stars of Pensacola, Florida, in the third championship game of Little League Baseball.

This was the first tournament to be called the "Little League World Series". Attendees at the championship game included Ford Frick, president of the National League (and later Commissioner of Baseball).