The 2016 Little League World Series was held from August 18 to August 28 in South Williamsport, Pennsylvania. Eight teams from the United States and eight from throughout the world competed in the 70th edition of the Little League World Series. Maine-Endwell Little League of Maine-Endwell, New York, defeated East Seoul Little League of Seoul, South Korea, in the championship game by a 2–1 score. It was the first Little League World Series title for a team from the United States since 2011, and for the state of New York since 1964, and the third overall.

Regional qualifying tournaments were held between June and August 2016.

The draw to determine the opening round pairings took place on June 16, 2016.

Teams that lost their first two games played a crossover game against a team from the other side of the bracket that also lost its first two games. These games were labeled Game A and Game B. This provided teams who were already eliminated the opportunity to play a third game.

This consolation game is played between the loser of the United States championship and the loser of the International championship.

The Maine-Endwell Little League became only the third team from New York state to win the Little League World Series (the others were Schenectady in 1954 and Staten Island in 1964). The MELL reached the LLWS with an undefeated record of 19 wins and no losses; in total, their record was 24–0.

Players Michael Mancini of New York (Vanderbilt) and Patrick Forbes of Kentucky (Louisville) played versus each other in NCAA D1 baseball tournament regional in 2025 after playing versus each other in the 2016 semifinal

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