Qualification for the Little League World Series in Mexico, whereby teams based in Mexico compete to select a champion to participate in the Little League World Series (LLWS), has occurred since 2001. In 2001, when the LLWS expanded to 16 teams, the Mexico Region was created as one of eight international regions, resulting in Mexico's Little League champion receiving an automatic berth in the LLWS. Mexico previously competed as part of the Latin America Region, from 1958 to 2001, whereby the champion from Mexico had to compete against teams from other countries in order to secure a berth in the LLWS.

Mexican teams have won three LLWS championships (1957, 1958, 1997) and have been runner-up three times (1964, 1985, 2008). The country currently^[when?] has about 450 active leagues, making it the third-largest country in terms of Little League participation.

Since 2001, when the Mexico Region was created.

The table below lists the records of teams from Mexico that have competed in the LLWS in South Williamsport, Pennsylvania. Participation before 2001 was inconsistent (for example, only one appearance during the 1970s), as teams from Mexico had to qualify via the Latin America Region. Since 2001, Mexico receives an automatic berth in the LLWS, with the exception of 2020 (when no LLWS was held) and 2021 (when the LLWS was restricted to teams based in the United States) due to the COVID-19 pandemic. Notably, teams from Mexico have twice represented regions of the United States in the LLWS:

As of the 2025 Little League World Series.

Roster

Manager

Coaches