The 1959 Little League World Series took place from August 25 through August 29 in South Williamsport, Pennsylvania. The Hamtramck National Little League of Hamtramck, Michigan, defeated the West Auburn Little League of Auburn, California, in the championship game of the 13th Little League World Series (LLWS). Hamtramck became the first team from the United States to win a championship since foreign teams were allowed to participate beginning in 1957. Hamtramck became the first team from Michigan to win the LLWS; the next Michigan champion was Taylor North in the 2021 edition.

This was the first year that the LLWS was played at Howard J. Lamade Stadium in South Williamsport. Two-time defending champion Monterrey, Mexico, was ruled ineligible to compete due to violations of player residency requirements.

† The European qualifier, from Bad Kissingen Airfield West Germany, was unable to travel to the tournament.