The 2021 Little League World Series was held from August 19 to August 29 at the Little League headquarters complex in South Williamsport, Pennsylvania as the 74th edition of the Little League World Series. Due to the COVID-19 pandemic, the event was limited to US-based teams only. The most recent prior edition of the tournament contested without international teams had been 1975. Taylor North Little League of Taylor, Michigan, defeated West Side Little League of Hamilton, Ohio, in the championship by a 5–2 score. It was the first championship for a team from Michigan since 1959.

On August 13, it was announced that tickets would not be distributed to the public due to concerns over the Delta variant, with spectators limited to invited friends and family of teams, and other high-level supporters.

The 16-team field consisted of the top two teams from eight regional tournaments, contested during July and August.

The eight teams appearing on a grey background were placed in the Tom Seaver championship bracket, while the other eight teams were placed in the Hank Aaron championship bracket.

Ella Bruning of the team from Abilene, Texas, became one of the few girls who have competed in the Little League World Series.

The draw to determine the opening round pairings took place on June 18, 2021.

The championship game was a rematch of the Great Lakes regional final during the qualification stage, which was won by Michigan, 9–1.

The Taylor North LL reached the LLWS with an undefeated record in seven games. In total, their record was 16–1, with their only loss coming to Hawaii in the third round of double-elimination play in South Williamsport.